Brain-targeted drug delivery by manipulating protein corona functions

Advances in Targeted Drug Delivery

Advances in Targeted Drug Delivery

A proteomics-based methodology to investigate the protein corona effect for targeted drug delivery.

Here we introduce a proteomics methodology based on nanoliquid-chromatography tandem mass spectrometry (nanoLC/MS-MS) to investigate the "protein corona effect for targeted drug delivery", an innovative strategy, which exploits the "protein corona" that forms around nanoparticles in a physiological environment to target cells.

Brain tumor-targeted drug delivery strategies

Despite the application of aggressive surgery, radiotherapy and chemotherapy in clinics, brain tumors are still a difficult health challenge due to their fast development and poor prognosis. Brain tumor-targeted drug delivery systems, which increase drug accumulation in the tumor region and reduce toxicity in normal brain and peripheral tissue, are a promising new approach to brain tumor treatm...

Brain Mini-Workshop: Blood Brain Barrier and Targeted Drug Delivery

Drugs are currently being developed for the treatment of serious brain disorders including glioblastoma, Parkinson’s disease, and Alzheimer’s disease. These include chemotherapeutic drugs and those based on neurotrophic factors such as glial cell-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), and neurturin (NTN). Neurotrophic factors have therapeutic potential for...